Gastroprotective effect of swallow root (Decalepis hamiltonii) extract: possible involvement of H(+)-K(+)-ATPase inhibition and antioxidative mechanism.

Naik, Yogender and Jayaram, Smitha and Harish Nayaka, M. A. and Mr., Lakshman and Dharmesh, Shylaja M (2007) Gastroprotective effect of swallow root (Decalepis hamiltonii) extract: possible involvement of H(+)-K(+)-ATPase inhibition and antioxidative mechanism. Journal of ethnopharmacology, 112 (1). pp. 173-9. ISSN 0378-8741

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Abstract

The present study reports the antiulcer potentials of aqueous extract of swallow root (Decalepis hamiltonii Wight & Arn, SRAE) belonging to the family Asclepiadaceae. Swim stress-induced ulcers with an ulcer index (UI) of 6.0+/-0.01 was protected up to 43% and 72% at 100 and 200mg/kg b.w. of SRAE, respectively, similar to protection offered by ranitidine (79%) at 30mg/kg b.w. Depletion in antioxidant enzymes and increased Thiobarbituric Acid Reactive Substances (TBARS) were observed in ulcer-induced rats while SRAE fed rats showed normal levels. SRAE also normalized approximately 3.1 and 2.4 folds of increased H(+)-K(+)-ATPase and gastric mucin, respectively, in ulcerous animals, similar to the levels found in healthy controls. SRAE also possessed reducing power, free radical scavenging ability with an IC(50) of 0.17microg/mL gallic acid equivalent (GAE), comparable to that of BHA (IC(50)-0.08microg/mL). DNA protection up to 80% at 0.2microg was also observed. Toxicity studies indicated no lethal effects in rats fed up to 5g/kg b.w. Antioxidant, proton pump inhibition as well as boosting of gastric mucin effects of SRAE have been implicated to be responsible for antiulcer property of SRAE.

Item Type:	Article
Uncontrolled Keywords:	Decalepis hamiltonii; Swallow root; Swallow root aqueous extract; Gastric ulcer; H+–K+–ATPase; Antioxidant
Subjects:	500 Natural Sciences and Mathematics > 10 Plants > 06 Trees And Shrubs 600 Technology > 08 Food technology > 32 Antioxidants
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	18 Aug 2008 10:41
Last Modified:	18 Nov 2016 11:11
URI:	http://ir.cftri.res.in/id/eprint/1875

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