Strain improvement of Aspergillus niger for the enhanced production of asperenone

Chidananda, C. and Mohan Kumar, C. and Sattur, A. P. (2008) Strain improvement of Aspergillus niger for the enhanced production of asperenone. Indian Journal of Microbiology, 48. pp. 274-278.

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Abstract

The enhancement of production of asperenone (Fig. 1), an inhibitor of lipoxygenase and human platelet aggregation from Aspergillus niger CFTRI 1105, was achieved by UV and nitrous acid mutagenesis. Nitrous acid mutants exhibited increased inhibitor production when compared with UV irradiated mutants. I N 41 a fi rst-generation nitrous acid mutant produced 5.1 fold increased asperenone over parent strain. Mutant II N 31 obtained by second-generation nitrous acid treatment produced 60.3 mg asperenone/g biomass, which was 131 fold increase when compared to fi rst generated mutant I N 41 and 670 fold increase over the parent strain. This mutant was stable for several generations on production medium.

Item Type:	Article
Uncontrolled Keywords:	Asperenone · Aspergillus niger · Mutagenesis · Nitrous acid · UV irradiation
Subjects:	600 Technology > 05 Chemical engineering > 04 Fermentation Technology 500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology > 04 Fungi
Divisions:	Fermentation Technology and Bioengineering
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	02 Jan 2009 11:16
Last Modified:	28 Dec 2011 10:07
URI:	http://ir.cftri.res.in/id/eprint/8865

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