Chidananda, C. and Mohan Kumar, C. and Sattur, A. P. (2008) Strain improvement of Aspergillus niger for the enhanced production of asperenone. Indian Journal of Microbiology, 48. pp. 274-278.
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Abstract
The enhancement of production of asperenone
(Fig. 1), an inhibitor of lipoxygenase and human platelet
aggregation from Aspergillus niger CFTRI 1105, was
achieved by UV and nitrous acid mutagenesis. Nitrous
acid mutants exhibited increased inhibitor production when
compared with UV irradiated mutants. I N 41 a fi rst-generation
nitrous acid mutant produced 5.1 fold increased
asperenone over parent strain. Mutant II N 31 obtained by
second-generation nitrous acid treatment produced 60.3 mg
asperenone/g biomass, which was 131 fold increase when
compared to fi rst generated mutant I N 41 and 670 fold
increase over the parent strain. This mutant was stable for
several generations on production medium.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Asperenone · Aspergillus niger · Mutagenesis · Nitrous acid · UV irradiation |
| Subjects: | 600 Technology > 05 Chemical engineering > 04 Fermentation Technology 500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology > 04 Fungi |
| Divisions: | Fermentation Technology and Bioengineering |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 02 Jan 2009 11:16 |
| Last Modified: | 28 Dec 2011 10:07 |
| URI: | http://ir.cftri.res.in/id/eprint/8865 |
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